Round 1 winner Eli Iserbyt (Pauwels Sausen-Bingor) will miss the second boom to stay fresh for the World Cup in Bern, Switzerland, the following day.
However, the World Cup will be off until Round 4 in Tabor, Czech Republic, on November 16, allowing Yzerbito to focus on regaining the lead in the Super Prestige Series.
He will be pushed hard by his Hellmans Telenet Baloise Lions teammate Toon Arts.
In the women's race, Canto will have to defend his one-point lead over Creafin-Fristads' Eva Lechner, winner of the Super Prestige Series opener two weeks ago in Gieten, the Netherlands Ceylin del Carmen Alvarado (Corendon-Circus) is just one point behind in third place overall.
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